Navigating the world of clinical skincare can be challenging, especially when trying to combine products to maximize their benefits. However, some active ingredients shouldn’t be used together.  That’s because they may become unstable, increase irritation or even cancel each other out when layered.  Understanding these combinations is important.  Revercel is committed to helping you design a effective, safe clinical skincare routine.  Here are some ingredient combinations to be mindful of: 


  1. Retinol and Vitamin C 

Retinol and Vitamin C are powerful antioxidants that work best under different conditions and at different pHs. Retinol is a derivative of vitamin A that increases cell turnover and promotes collagen production. It’s best applied at night because it can make the skin more photosensitive in the daytime, increasing the risk of sun damage. Vitamin C, on the other hand, is an antioxidant that works best in an acidic pH environment to protect the skin from free radicals.  Vitamin C is more than an antioxidant; it also has sunscreen properties and is therefore best used during the day. Applying these antioxidants together can cause irritation, especially for sensitive skin. Use them at the times they’re intended: vitamin C in the morning and retinol at night. 


  1. Retinol and AHAs/BHAs  

Alpha Hydroxy Acids (AHAs) and Beta Hydroxy Acids (BHAs) are excellent exfoliants that help remove dead skin cells and improve texture. However, when combined with retinol, these acids can over-exfoliate the skin, leading to increased sensitivity.  For optimal results, use retinol and AHAs/BHAs on alternate days to avoid redness, flaking and peeling. 


  1. Glycolic Acid and Salicylic Acid 

Glycolic acid (an AHA) and salicylic acid (a BHA) are effective exfoliants but using them together can overwhelm the skin. This combination can cause dryness, irritation, and increased sensitivity.  It's best to alternate between these acids, using glycolic acid one day and salicylic acid the next. This approach allows for effective exfoliation without irritation. 


  1. Glycolic Acid and Vitamin C  

Glycolic acid, an AHA, exfoliates the skin to promote cell turnover and a smoother texture.  Vitamin C is an antioxidant that protects the skin from free radicals and brightens the complexion.  However, when used together, these ingredients can be irritating, especially for sensitive skin. Glycolic acid can lower the pH of vitamin C, making it less effective and more irritating. Therefore, apply products containing vitamin C in the morning and glycolic acid products in the evening. This separation helps each ingredient work optimally without adverse reactions. 


Revercel is committed to helping you achieve an effective clinical skincare plan. We offer five physician strength Treatment Kits for dry, sun damaged, combination, sensitive or acne-prone skin.  Attractively priced, each Kit contains morning and evening products that synergistically work together — without compromising your skin's health